GENE THERAPY IN CHEST DISEASES

Many genetic and acquired lung diseases are potential targets for gene therapy. The initial enthusiasm associated with gene therapy has now been replaced by recognition of the great difficulties inherent in this endeavor. Several viral and nonviral vectors have been demonstrated in preclinical studies to be suitable for pulmonary gene delivery. However, problems with efficiency and host immune response remain to be solved. Given the rapid progress the field has made, it is likely that clinical application of gene therapy to pulmonary diseases will become a reality in the next decade (West and Rodman,2001).AIM OF THE WORKThrough some light on the efficacy of gene therapy in chest diseases.