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Finally, I wish to express my deep thanks to Allah, by the grace of whom the progress and completion of the present work was made possible.I am greatly indebted to Prof. Dr. Mohamed Mamdoh Gaafar Professor of Pediatric, Faculty of Medicine, Zagazig University for his unfailing encouragement, sincere guidance, valuable suggestion, constructive opinions throughout the whole work and his everlasting patience.I would like to express my deep gratitude and appreciation to Prof. DR. Olivia Saad Eldin Ashmawy Professor of Pediatric, Faculty of Medicine, Zagzaig University for her scientific insight, kind supervision, precious advice, and unlimited help to accomplish this work.My sincere appreciation to Prof. Dr. Hanan Amin Abdel Rhman Assistant Professor of Pediatric, Faculty of Medicine, Zagazig University for her constant guidance, encouragement, and her everlasting willingness to spare no effort nor time to help in putting this work in its final form.Special thanks are owed to Prof. Dr. Somia Hassan Abd Alla Assistant Professor of Biochemistry, Faculty of Medicine, Zagazig University for his help regarding the laboratory part of the work. I am also grateful to him for graciously lending a hand whenever needed all over the stages of the work.
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