study of bone marrow transplantation

Haemopoiesis starts with a common pluripotent stem cell that can give rise to the separate cell lineages. The hematopoietic system is characterized by constant turnover of cells to maintain populations of leukocytes, platelets and erythrocytes. Stem cell has the ability of self renewal and differentiation which are regulated by growth factors, stromal cells of hematopoietic microenvironment and intracellular mechanisms. Bone marrow transplantation involves eliminating and replacing an individuals bone marrow stem cells and all cells derived from them including the haemopoietic, lymphoid and histocyte/ macrophage system by a healthy marrow grafts . Bone marrow grafts are derived from syngeneic, allogeneic or autologus sources. The sources for stem cell for transplantation include bone marrow, peripheral blood, cord blood and fetal liver tissue.