ROLE OF ANTIOXIDANTS IN THE LUNG OF DIABETIC MALE ALBINO RATS

ABSTRACTDiabetes is a chronic disease characterized by hyperglycaemia. The present work was carried out to study the histological changes of the lung with diabetes and to study the role of using antioxidants in prevention of diabetic lung complications. For this purpose, fifty male adult albino rats were utilized. Alloxan was used for induction of diabetes. The diabetic rats were classified into two groups: diabetic only (group B) and the vitamin treated group (C). The rats in group (C) were supplemented with vitamin E and A. The diabetic lung showed expansion of the lung interstitium by collagen fibers, proliferated pneumocyte type II and many inflammatory cells. The cytoplasm of pneumocyte type II showed dilated rough endoplasmic reticulum and glycogen granules. Also, lipid droplets were seen in the interstitial cells. The lung of diabetic rats treated with vitamin (E&A) (group C) showed relatively less collagen fibers and inflammatory cells than that of the corresponding diabetic group.In conclusion, uncontrolled experimental diabetes induces several histological changes in the lung that are more prominent with the progression of the disease and could explain the respiratory manifestations of diabetes. So, supplementation of vitamin E&A is recommended in the diabetic regimen in order to keep diabetic patient as healthy as possible and enjoy life with diabetes.