Study of Serum Level Of Cardiotoxic Lipid Peroxidation Products In Type 2 DM

Type 2 diabetes per se is not only one of the major cardiovascular risk factors but also provides and is associated with other major cardiovascular risk factors such as dyslipidemia , obesity and hypertension. There is a number of equally tenable hypotheses on the origin of diabetic complications , one of them is the oxidative stress .Lipid peroxidation can be defined as the oxidative deterioration of lipids containing any number of carbon-carbon double bonds. The process whereby free radicals “steal” electrons from the lipids in the cell membranes, resulting in cell damage and increased production of free radicals. Therefore, lipid peroxidation is a radical-initiated chain reaction that is self propagating in cellular membranes. During lipid peroxidation, a significant number of aldehydes are formed by break of lipid hydroperoxides, the majority of them are high reactive and can be regarded as the 2nd toxic messengers which increase the initial damage due to the free radicals; 1st toxic messengers. The aldehydes best studied are 4-hydroxynonenal, and malondialdehyde . These products not only react with antioxidants like the glutathione, increasing the radicalizing stress, but also allowing their detoxification and they had cytotoxic, hepatotoxic, mutagenic and genotoxic properties and play a role in the genesis of atherosclerosis and heart diseases .There has been considerable recent debate regarding the extent to which increased oxidative stress contributes towards the development of diabetic complications .Therefore , the present study was designed to study the serum levels of lipid peroxidation products (LPPs) in type 2 diabetic patients : with or without ischemic heart disease, in comparison to control subjects and to find