The correlation between liver enzymes, eosinophilia and the histopathological picture, as a clue to preliminary diagnosis of both acute and chronic fascioliasis in experimental animals

Fascioliasis is well-known parasitic disease because of its veterinary importance. Human fascioliasis was only considered a secondary disease by public health officials. This picture has changed in recent years; the pathogenicity of fascioliasis in humans has been recognized (Mas-Coma, 1999). Reports of human infected by Fasciola hepatica have been significantly increasing since 1980 worldwide. Globally several million people are estimated to be infected (Esteban, 2002). Fascioliasis causes; severe symptomatology and pathology (Mas-Coma et al., 2000).The migratory larval and the resting adult stages of Fasciola life cycle correspond to two clinical stages of infection called the acute and chronic stages. Symptoms occur in 80% to 90% of patients and include fever, abdominal pain. Eosinophilia is very common. After two to four months the chronic biliary stage gradually replace the acute stage, the patient may become asymptomatic or have episodes of biliary manifestations that can persist for a decade or more (Arjona et al., 1995).As the diagnosis of acute fascioliasis is based on clinical suspicion, familiarity with the disease is necessary to improve the clinical acumen. In Egypt, children appear to be the most affected (Esteban, 2003). As the infectious hepatitis A is common during this age and biliary disorders are common later. It is logic to differentiate these manifestations on basis of serum enzyme assays and serum enzyme immuno assay.So this study aimed to evaluate the role of both assays in the light of induced pathology in mice and rabbits infected by viable encysted metacercariae of Fasciola hepatica.