Expression Of Apoptosis Suppressing Bcl.2 Protein, Ps3 Suppressor Gene Product In Bilharzial And Non Bilharzial Carcinoma Of The Urinary Bladder

Alternations in the function of P53 gene are frequent events in bladder cancer. In the current study, immunoreactivity for P53 highly correlated with tumor grade. P53 over expression was much more higher in invasive and high grade urinary bladder cancer, in conjunction with the findings thatinactivation of P53, may be an early event, suggests that it may be associated with the evolution of aggressive growth characteristics in bladder cancer, and poorer clinical out come. In our study bcl-2 immunostaining was typically cytoplasmic in superficial bladder cancer grade I and II. In invasive tumors however, bcl-2 positive cells were rarely observed these findings suggest that, bcl-2 gene abnormalities may reflect the genetic instability of bladder tumors, it does not prolong cell survival in the transitional epithelium, with associated risk of malignant transformation, it is associated witha less aggressive phenotype, and does not contribute to tumor progression in bladder cancer.In our study the association of bcl-2 immunoreactivity with tumor stage and grade was not significant, suggesting that immunohistochemical analysis of bcl-Z expression has a little use as a prognostic marker in bladder cancer. Subsequently we found no correlation between apoptosis, as evaluated by bcl-2 expression, and prognosis in bladder cancer.