Molecular biology of haemophilia (A) in children

the aim of this work is to screen and identify the mostcomon type of mutation which is inversion of intron 22 occuring inthe facor VIn gene and if there is relation between the presence ofinhibitors and mutation or not.This work has been done at Zagazig University prediatricdepartment in the clinic of haematological diseases.This study include 12 haemophilic child who are previouslydiagnosed by measuring of factor VIII level and who are regularlyattend to the haematologic clinic for plasma or cryoprecipitate or--11.’.factor VIII transfusion and their 12 mothers, 12 sisters.