Values Of Retinol Binding Protein (RBP) And Microalbuminuria As Early Predicators Of Nephropathy In Diabetes Mellitus Type 2

Diabetes mellitus is a group of metabolic disease characterized byhyperglycemia resulting from defects in insulin secretion, insulinaction onboth the chronic hyperglycemia of diabetes is associated with long termdamage, dysfunction, and failure of various organs, especially the eye,Kidneys, nerves heart and blood vessels.Diabetic nephropathy is one of the most serious long term..c. complications of D.M. this DN begins from nonnoalbuminuria to end stagerenal disease, through intermediate stages marked by microalbumin and overtproteinuria causing considerable morbidity and mortality.It is well established that the detection of microalbuminuria in adiabetic patient indicates the glomerular involvement in early renal damage,whereas decrease of serum level of retinol protein (RBP) indicates proximaltubular involvement.The aim of this study is to evaluate the values of urinary microalbuminexcretion as a marker of glomerular dysfunction and that of RBP as a markerof tubular dysfunction in diabetic nephropathy.The present study comprised 30 patients with type 2 diabetes mellitus(NIDDM) and 10 apparently healthy controls. Patients and controls weresubjected to the follows:-1P Detailed history taking and full clinical examination2- Routine laboratory investigations which include:- Fasting, post parricidal blood glucose leveL- Blood urea, serum creatinine.- Liver function tests.- Complete urine analysis.- Glycated hemoglobin.3- Special investigations:- Microalbumin by turbidimetry.- Serum retinol binding protein by EU!A.