This work was done in hope to clarify the role of breast milk as a vehicle foraflatoxin and ochratoxin in the infants and impact’of them in lactating infants.50 exclusively healthy lactating mothers and their healthy exclusively lactatinginfants, for at least 4 months, were included in this study. Full physicalexamination was done for both infants and mothers. Samples of blood and breastmilk were collected from mothers and their infants and level of aflatoxin andochratoxin were detected. Serum creatinine, urea, uric acid, liver tests (ALT,AST, serum albumin and prothrombine time) were determined. Infants’ urinarymicroalbumin and B2-microglobulin levels were also determined.The results of this study showed that:-1- The mycotoxin detection rate was higher among mothers’ serum,mothers’ milk and serum of their exclusive breast feed infants.2- The contamination rate of ochratoxin was higher (72% for mothers’serum and milk) than that for aflatoxin (48% and 50% for mothersserum and mothers milk respectively) with higher positivecontamination rate in urban areas than in rural areas.3- The levels (mean ± S.D ug/rnl) of aflatoxin and ochratoxin were4.1715 ± 5.517 and 3.987 ± 4.0105 respectively in mothers’ serum,0.957 ± 1.036 and 1.1505 ± 1.003 respectively in mothers milk and0.858 ± 1.154 and 1.379 ± 1.92 in serums of their exculsive breast fedinfants, for aflatoxin and ochratoxin respectively.4- There was no statistically significant difference between urban andrural areas as regard to positive detection rate and levels of aflatoxinand ochratoxin for mothers’ serum, mothers’ milk and infants’ serum.85Summary,:. ’”’, . ’.._.’ .5- Mothers milk aflatoxin showed a significant positive correlation withinfants serum aflatoxin (P=0.008) and with mothers’ serum aflatoxin I\.(P=O,003),6- A significant positive correlation was noted between mothers’ milkochratoxin and mothers serum ochratoxin (P < 0.001), while there wasno statistical significant correlation between mothers’ milk ochratoxinand infants serum ochratoxin.7- There was a significant negative correlation (P=0.023) between infantsserum aflatoxin and the residual of regression of length/age.8- Both unne microalbumin and p2-microglobulin levels weresignificantly higher in infants positive for ochratoxin or for ochratoxinand aflatoxin than negative.9- For infants’ serum positive for aflatoxin, there was no significantalternation in their liver function findings.10- No statistical significant differences in kidney function tests amongmothers positive for ochratoxin and/or aflatoxin versus negative ones.11- There is statistically significant difference in prothrombin time inmothers’serum positive for aflatoxin.