Antifungal therapy New Concepts

Summary Fungal diseases are assuming increasing Lmpor t.ance I clinical medicine, and knowledge of the a n t i funga.L ’ugs with respect to spectrum of acti vi ty and toxicity essential. The ideal antifungal agent should possess the l Iow i ng charact.eristics: (1) potent activi t y against ngal pathogens, (2) flexibility of parenteral or oral ministration, (3) no toxicity, (4) favourable armacokinetics, including effective penetration into all ssue compartments, complete bioavailability and edictable adjustment, if any, of dosage in renal or patic insufficiency, and (5) low c o no antifungal agent which fulfill these aracterist ics. POTassium iodide was introduced in 1903 and a t i Ll, Ie drug of choice for Treatment of lymphocutaneous orot r i chos i sOne of the first classes of drugs used to treat erficial fungal infections was keratolytic agents, ich as, salicylic acid which enhances the shedding of ratum corneum and the organisms contained wi thin it Ie use of keratolytics in 1907 led to development of itfield’s ointment which contains both benzoic and.