SUMMARY, CONCLUSION AND RECOMMENDATIONHyperhomocysteinemia is one of the non-traditional risk factor for cardiovascular disease (CVD) in patients with chronic renal failure (CRF). The cause of hyperhomocysteinemia in CRF was suggested to be due to impairment of renal or extra renal metabolism caused by the strongly disturbed renal remethylation of Hcy to methionine which is only partly reversible by vitamin supplementation. Other causes of refractory hyperhomocysteinemia in ESRD patients are the reduced glomerular filtration and deranged tubular reabsorbtion.The present study was conducted on 35 patients with CRF and 15 age and sex matched healthy controls. These patients were selected from Nephrology Unit-Internal Medicine Department, Zagazig University Hospitals. All of them were subjected to full history taking, clinical examination and laboratory investigations including urea, creatinine, creatinine clearance, total protein, albumin, fasting glucose level, lipid profile, quantitative C-reactive protein, total plasma homocysteine level, vitamin B12 and folic acid.From this study the following results can be summerized:• Twenty four patients from CRF group were suffering from CVD (68.5%).• There was a significant increase in systolic and diastolic blood pressure in CRF group compared to control group. Twenty seven patients from CRF were hypertensive (77.1%). Hypertensive patients were 8.35 times more risky to have CVD than non-hypertensive patients (OR = 8.35, 95% CI = 1.36-65.48).• There was a significant decrease in total protein and albumin in CRF group compared to control group.• There was a significant increase in glucose level in CRF group compared to control group. Nineteen patients from CRF were diabetic (54.3%). Diabetic patients were 9 times more risky to have CVD than non-diabetics (OR = 9, 95% CI = 1.28-79.4).• There was a significant increase in total cholesterol, triglycerides and LDL cholesterol and a highly significant decrease in HDL cholesterol in CRF group compared to control group. Twenty five patients from CRF were dyslipidemic (71.4%). Dyslipidemic patients were 8 times risky to have CVD than patients with normal lipid profile (OR = 8, 95% CI = 1.28-57.39).• There was a highly significant increase of total Hcy in CRF group compared to control group. Twenty patients from CRF were hyperhomocysteinemic (57.4%). Hyperhomocysteinemic patients were 6.48 times more risky to have CVD than patients with normal Hcy level (OR = 6.48, 95% CI = 1.07-44.4).• There was a highly significant increase of vitamin B12 and folic acid in CRF group compared to control group.• There was a highly significant increase of CRP levels in CRF group compared to control group.• There was a highly significant positive correlation between Hcy and both urea and creatinine and a highly significant negative correlation between Hcy and creatinine clearance in CRF group.• There was a highly significant negative correlation between Hcy and both vitamin B12 and folic acid.The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .In this study , 75 patients included presented by abnormal uterine bleeding . Histological examination reveals that 15 cases (20%) proved to be endometrial carcinoma , 46 cases (61%) endometrial hyperplasia , 2 cases (3%) secretory endometrium , 5 cases (7%) proliferative endometrium , 6 cases (8%) atrophic endometrium , and only 1 case (1%) proved to be endometrial polyp . The sonographic finding in cases of endometrial carcinoma were charecterized by an endometrial thickness more than 10 mm . Non of the cases of endometrial carcinoma had endometrial thickness less than 10 mm , while all cases of atrophic endometrium had endometrial thickness less than 5mm . 32.6 % of cases of endometrial hyperplasia had endometrial thickness 5-10 mm , while 67.4 % more than 10 mm . The mean endometrial thickness of non malignant group was 11.23 + 6.04 while in malignant group was 20.67 + 6.58 and this was statistically significant (p< 0.001)Endometrial thickness greater than 13 mm , which is hypoechoic or inhomogenous with presence of intratumoral blood vessels with RISUMMARYEndomtrial carcinoma is the commonest invasive malignancy of the female genital tract in both the united kingdom and united states of America . It is the fourth commonest cancer in women and the most curable of the 10 most common cancers in women.Recents reports have investigated the role of transvaginal color Doppler ultrasonography as a means of detecteding gynecologic malignancies. Assessment of tumor angiogenesis using color Doppler ultrasound provides useful information for the preoperative prediction regarding stage, depth of myometrial invasion and presence of lymph node metastasis in patients with endometrial carcinoma .In this study , two groups of patient were included. Non malignant group comprised 60 patients and malignant group comprised 15 patients.All the patients in both groups were subjected to through history , through clinical examination and then TVS with color flow and pulsed Doppler study and finally from every patient endometrial biopsy was taken which was subjected to:- Routine histopathological examination .The results were statistically analyzed and diagnostic accuracy of Doppler ultrasonography in the prediction, diagnosis and prognosis of endometrial carcinoma are calculated .** This study proved that the relaxant effect of ADM upon pregnant uterine smooth muscles was mainly via ADM receptors.** Serum progesterone level was significantly increased throughout pregnancy suggesting that progesterone increased the levels of ADM receptors, indicating regulation by steroid hormones. The progesterone-stimulated increases in ADM receptors may be responsible for increased uterine relaxation sensitivity to ADM during pregnancy. Also, estrogen levels were increased progressively during gestation.Therefore, it was recommended that:** ADM plays an important role in uterine smooth muscle relaxation (uterine quiescence) that required for successful pregnancy and hence, the prevention of preterm labor and threatened abortion.