The aim of this study was to study apoptosis in both common and lesscommon types of colopathies in Egypt by detection ofBcl-2 oncogen via IHCstaining (inhibitor of apoptosis).This work was carried out on 90 cases, 15 with schistosomal colitis, 15with amoebic colitis, 15 with IBS, 10 with ulcerative colitis, 10 with benignadenomas, 10 with adenocarcinoma and lastly 15 normal controls. They weresubjected to; full history taking, complete physical examination, stoolIn human body, it is present in almost all cells especially the liver, kidneys, spleen, testes and pancreas and it is important for many body processes.Recently, selenium has been receiving huge attention due to the claims of its ability to maintain healthy immune function, its protective effects against cardio-vascular diseases, impaired thyroid function, cataract and macular degeneration and its ability to combate cancer and some chronic inflammatory processes such as rheumatoid arthritis.