NEW BIOCHEMICAL MARKERS FOR DIAGNOSIS OF RICKETS

The processes of bone formation and resorption can be monitored in vivo by measuring enzymes and other protein products released by osteoblasts and osteoclasts respectively. The major validated biochemical markers of bone formation currently in use include the bone isoenzyme of alkaline phosphatase, osteocalcin and propeptides derived form the N or C terminal ends of the type I procollagen molecule. The most useful markers of bone resorption are breakdown products of type I collagen (Russel 1997).The objective of this study is to evaluate new biochemical markers for the diagnosis of various types of rickets..