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Antihepatotoxic Activity of Phyllanthus atropurpureus Cultivated in Egypt
Faculty
Pharmacy
Year:
2011
Type of Publication:
Article
Pages:
447-452
Authors:
Zayed, Rawia, Sarg, Taha, Ghani, Afaf Abdel, El-Sayed, May
Journal:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES VERLAG Z NATURFORSCH
Volume:
66
Research Area:
Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy
ISSN
ISI:000297960200002
Keywords :
Phyllanthus, Euphorbiaceae, Hepatoprotective Activity
Abstract:
The genus Phyllanthus (family Euphorbiaceae) is considered one of the important medicinal and ornamental plants. A phytochemical analysis of the extracts was performed to search for the active ingredient. Results of the investigation of the hepatoprotective activity of Phyllanthus atropurpureus Boj. Hort. Maurit. revealed that the activities of alcoholic extracts of its aerial parts and roots were quite similar to those of silymarin. Both of them improve the parameters of CCl(4)-induced liver injury including serum aspartate aminotransferase and alanine aminotransferase. Among the extracts tested, the root extract showed maximum activity compared to the aerial parts extract and to silymarin.
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