Urinary N-acertyl-B-D glucos Aminidase as A marker for early detection of renal tublar disturbance in patients with iddm (TYPEI)

This study is carried out to evaluate the level of urinary NAG inIDDM (type I) patients and its relation to microalbuminuria, duration ofdiabetes and diabetic control.Renal impairment is an important feature of diabetes mellitus,causing significant morbidity and mortality, and much effort has beendevoted to the detection of this complication at a stage when it is silent andpotentially reversible.It has been shown that microalbuminuria reliably predicts a high riskof the subsequent development of progressive and fatal renal disease ininsulin dependent diabetes mellitus.The increased albumin excretion is usually considered to be ofglomerular origin, but there is evidence to suggest that tubular malfunctionmay also contribute.