| Abstract: |
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that may affect any organ of the body and display a broad spectrum of clinical and immunological manifestations ( Cervera et al., 2003).This study was performed to determine the serum level of anti-chromatin antibodies in a random sample of SLE patients in comparison with healthy volunteers and to study its relation with disease activity and organ involvement in these patients.Subjects and Methods :The study was performed on 50 subjects who were divided into two groups; the SLE group and the control group. The SLE group included 30 SLE patients who were chosen randomly and diagnosed according to the American Rheumatism Association Criteria for classification of SLE and were further divided according to the SLEDAI score into an active group (n=13) and an inactive group (n=17). The control group included 20 apparently normal volunteers age and sex matched with the SLE patients.All patients were subjected to full history taking, complete clinical examination, disease activity assessment by the SLEDAI score, laboratory investigations including complete blood picture,erythrocyte sedimentation rate, C-reactive protein, complete urine analysis, protein in 24 hour urine, liver and kidney function tests, ANA, Anti-dsDNA titre, complement 3, complement 4 and Anti-chromatin antibodies.
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