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Effect of chromatographic conditions on liquid chromatographic chiral separation of terbutaline and salbutamol on Chirobiotic V column
Faculty
Pharmacy
Year:
2011
Type of Publication:
Article
Pages:
6727-6731
Authors:
Hashem, Hisham, Jira, Thomas, Truendelberg, Clemens, Attef, Omer
DOI:
10.1016/j.chroma.2011.07.090
Journal:
JOURNAL OF CHROMATOGRAPHY A ELSEVIER SCIENCE BV
Volume:
1218
Research Area:
Biochemistry \& Molecular Biology; Chemistry
ISSN
ISI:000295432700019
Keywords :
Enantioseparation, Terbutaline, Salbutamol, Chirobiotic V, Polar ionic mode
Abstract:
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100\% ethanol, pH 5.1 was found to give the best separation. The salt concentration in the mobile phase and pH value were found to be the most important chromatographic factors affecting separation. Separation of enantiomers of these two basic analytes was complete in less than 10 min without applying ammonium trifluoroacetate (ATFA) or triethylamine (TEA) salts. (C) 2011 Elsevier B.V. All rights reserved.
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