| Abstract: |
Hepatic Failure is simply defined as a failure of the liver toperform its function.It can complicate almost all forms of liver diseaseand this will result in disturbances of different body systems especially,severe neurological manifestations due to advanced Hepa __ tic failure e.g.:in cirrhotic patients and usually among Egyptins of chronic bilharziasis.Although the clinical features of Hepatic Failure may differdepending upon the severity and duration of the disease, they are minimalwith no encephalopathy. One of the important features is -Iaundice owingto failur of the liver cells to deal with bilirubin resulting inHyperbilirubinaernia, but, the overall picture and lines of treatment aresimilar irrespective of the aetiology.Hyperbihrubinaernia in infants and children has been reported tocause sensorineural hearing loss but no such studies has been reportedabout the effect of Hyperbilirubinaemia in adults with Hepatic Failure onhearing.So, this study tries to show the hearing profil in patients withhepatic failure aiming to:Determine the effect of Hepatic Failure on Hearing.Correlate between duration of Hepatic Failure and Hearing loss.Correlate between Hyperbilirubinaernia and Hearing loss.Determine the effect of drugs used during history and managmentof Hepatic Failure on Hearing.Afourty patients with Hepatic ”Failure that reffered to the AudiologyUnit in ENT. Department by Internal Medicine Department of ZagazigUniversity Hospitals, were used as study group and other twenty normalsubjects were chosen randomly from relatives of pa.Lients and theAudiology U ni t personell as a control group.The subjects of ages, in both groups, ranged between 22-65 yearsand each one of them was subjected to the following: full investigationsincluding; History, Medical exam, Otological exam, Audiologicalevaluation using Pure Tone Audiometer.rjbne decay and Tympanometryand Laboratory investigations for the study group only especially totalserum bilirubin level.It is, there-fore, recommended that:- Patients with Hepatic Failure must be assessed audiologically,- Auditory Brain-stern Response, ABR, is needed for audiologicalassessment of patients with Hepatic Failure.- Drugs used in treatment of Hepatic Failure might be given orally inpresence of vitamine A and B-complex with caution and closeaudiological follow up.- Further, Histopathological studies about the effect of bilirubin on thecochlea by means of electronmicroscopy are needed.
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