pharmacokinetics of psoralen in relation to puva treatment

The advent of successful photochemotherapy raises the question of what proper formulation could be used which may give an optimal photosensitizing effect during puva therapy. Agood formulation should aim at an early and predicatable tmax and high reproducible serum concentration, this would probably lead to the lowering of mpd. Since low mpd and thus the initial therapeutic uva does requirements are lowered, does increments during therapy can start from alower dose level. This leades to areduction of total cumulative uva does required for the whole treatment . accordingly the risk of long-term puva side-effects will be lowered.