This study was carried out in Medical Biochemistry and OutpatientDialysis Unit of Internal Medicine Departments, Faculty of Medicine,Zagazig University. It included a total number of 40 subjects who weredivided into four groups and were crossly matched with age. sex andsocioeconomic level.These groups were:Group I included 10 apparently healthy volunteers. They have nohistory of kidney disease or any other diseases which may interfere withstudied parameters.Group II included 10 chronic renal failure patients on conservativetreatment whom received no dialysis at all.Group III included 10 chronic renal failure patients on regularhemodialysis.Group IV included 10 chronic renal failure patients on regularperitoneal dialysis.All groups were subjected to the following:1-Full clinical history including age, occupation and complete medicalhistory taking.2-Full clinical examination to detect signs of kidney diseases and toexclude other diseases that may interfere with studied parameters.3-Chest X-ray and abdominal ultrasonography.serum creatinine and blood urea.serum sodium and potassium level and kidney function tests includinglevel, urine and stool analysis, liver function tests, blood glucose level•,4-Routine laboratory investigation; including complete blood picture. I-lb level, urine and stool analysis, liver function tests, blood glucose level serum sodium and potassium level and kidney function tests including serum creatinine and blood urea.