COMPARATIVE STUDY OF SOME TOXICOLOGICAL ASPECTS OF CHLORAMBUCIL AND CYCLOPHOSPHAMIDE ON ALBINO RATS

The aim of this work is to compare and evaluate some of e toxicological hazards of long term administration• of both drugs by j.studying :1- Their effect on chromosomal pattern in rat’s bone marrow.Histopathological effect on liver, kidney, ovaries, testes, bone marrow and spleen by light microscope.Immunological changes in T-lymphocytes in bone marrow and spleen..