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Spectrscopic and Conductometric Analysis of Gabapentin
Faculty
Pharmacy
Year:
2011
Type of Publication:
Article
Pages:
1784-1796
Authors:
Anis, Sara M, Hosny, Mervat M, Abdellatef, Hisham E, El-Balkiny, Mohamed N
Journal:
E-JOURNAL OF CHEMISTRY WWW PUBL PTE
Volume:
8
Research Area:
Chemistry
ISSN
ISI:000299682400039
Keywords :
Cupric chloride, Bromothymol blue, Bromocresol green, Spectrophotometrically, Conductometric technique
Abstract:
Four simple, sensitive and reproducible methods were developed for the determination of gabapentin (GPT) in pure form and in pharmaceutical preparations. Methods A and B are based on the reaction of cupric chloride with gabapentin to form stable complex, which could be measured spectrophotometrically at lambda(max) 246 nm (method A) or by using conductometric technique (method B). While method C and D depends on the formation of ion pair complex between the studied drug and bromothymol blue, bromocresol green respectively this was extractable with methylene chloride. The concentration ranges were 40-95 mu g mL(-1), 1-15 mg, 100-800 and 10-150 mu g mL(-1) for methods A, B, C and D respectively. The optimization of various experimental conditions were described. The results obtained showed good recoveries, Ringbom optimum concentration ranges were calculated, in addition to molar absorptivity and sandell's sensitivity, detection and quantification limits. The methods were successfully applied to the determination of GPT in bulk and pharmaceutical preparations. The results were favorably comparable with the official method. The molar combining ratio for methods (A-B) was found to be (2:1) (drug: reagent) while for method (C-D) it was found to be (1:1).
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