multiple organ involvement in perinatal asphyxia

SUMMARY AND CONCLUSIONDysfunction of organs other than the central nervous system is often recognized after perinatal asphyxia. However, few studies have assessed multisystem involvement in severely asphyxiated neonates.Little is known about the relationship between the traditional perinatal markers of asphyxia and multiple organ involvement.The aim of this study is to evaluate the frequency and spectrum of severity of multisystem dysfunction in the neonatal period after a perinatal asphyxial insult, and to analyze the relationship between the traditional clinical and biochemical markers of perinatal asphyxia and multiorgan dysfunction to determine whether any of those early markers might help to identify promptly the asphyxiated neonates at risk of multiorgan involvement.The study was conducted on twenty full term newborn infants with perinatal asphyxia who were subjected to full history taking particularly of obstetric data e.g. maternal diabetes, pre-eclampsia, antepartum haemorrhage, Apgar score at birth, onset of breathing:- Neurological evaluation, level of consciousness,- Presence of seizures, tone and reflexes, occurrence of apnea.- Cranial sonography performed to all infants within 1 week.- Computed sonography performed to survived infants with abnormal Sonographic findings at 4 weeks of age.