Study of Megakaryocyte Ploidy in Patients with Abnormal Platelet Counts

this study was carried out at clinical pathology department faculty of medicine, zagazig university at the period from 10 2001 to 4/2002. this study included 50 subgects classified into 6 groups.Study of Megakaryocyte Ploidy in Patients with Abnormal Platelet CountsPatients with Abnormal Platelet Countsfrom this study we concluded that:* Flow cytometric analysis of MK ploidy distribution in patients withthrombocytopenia may be diagnostically useful by discriminatingbetween disorders of platelet production and destruction.* The modal ploidy distribution in normal human bone marrow is 16 N.* There is shift to the low ploidy MKs with thrombocytopenia secondary tohypersplenism, thrombocytopenia due to impaired platelet productionand CML associated with thrombocytosis.* There is shift to the high ploidy MKs with ITP and reactivethrombocytosis.* No correlation between platelet count and megakaryocyte ploidy.