The study ofVEGF expression in different skin diseases helps to elucidate angiogenic pathology in these diseases. Dermatology may be one of the first disciplines to benefit from new discoveries in the field of angiogenesis due to the importance of angiogenesis in many pathological conditions and the ease of delivery of agents to the skin.Psoriasis is an inflammatory and angiogenic disorder. The initial inflammatory stimulus is not known, but it is likely that angiogenesis is necessary to maintain the inflammation by allowing entrance of neutrophils and lymphocytes into psoriatic lesion. Thus, antagonizing the angiogenic effect of VEGF may provide a novel method for the treatment of psoriasis as well as other inflammatory skin diseases.VEGF has an important role in tumor growth and invasion and may be a determinant oftumor survival and metastasis, so anti-VEGF antibodies can be used in the treatment of cancer.VEGF plays an important role in the increased microvascular permeability and resulting edema, fibrin deposition, and bulla formation characteristic of bullous erythema multi forme and other bullous dermatoses characterized by subepidermal blister formation.Trials to identify molecules that might down regulate the expression of VEGF with its high affinity receptors on endothelialcells in these diseases, may be helpful for new therapeutic trials. Similar approaches might be applicable to the treatment of other skin diseases that are characterized by angiogenesis such as psoriasis and skin malignancies. In contrast, the angiogenic activity of VEGF is sufficiently potent to induce a therapeutic effect. It can be used for therapeutic induction of angiogenesis that may be beneficial in the treatment of delayed wound healing, chronic venous ulcers, arterial insufficiency and enhancing graft survival.• This study emphathies the importance of VEGF in thepathogenesis of psoriasis, basal cell carcinoma, squamous cell carcinoma and bullous erythema multiforme. Further studies for the expression of VEGF in other skin diseases may be helpful in understanding of other aspects in the pathogenesis of these diseases.• The important role ofVEGF in the pathogenesis of certain skindiseases as psoriasis and skin cancers directs the attention for using anti-VEGF agents for the treatment of these diseases.• The angiogenic properties of VEGF can be utilized fortherapeutic purposes as in improving wound healing and enhance skin graft survival, and in the treatment of chronic venous ulcers and arterial insufficiency.• As normal hair growth and size are dependent on VEGF-induced perifollicular angiogenesis, therapeutic uses ofVEGF and its antagonists in disorders of hair growth could be the target for future research studies.