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Correlation between musculoskeletal function and radiological joint scores in haemophilia A adolescents
Faculty
Not Specified
Year:
2011
Type of Publication:
Article
Pages:
920-925
Authors:
Hassan, T. H, Badr, M. A, El-Gerby, K. M
DOI:
10.1111/j.1365-2516.2011.02496.x
Journal:
HAEMOPHILIA WILEY-BLACKWELL
Volume:
17
Research Area:
Hematology
ISSN
ISI:000297214100019
Keywords :
adolescents, functional independence score in haemophilia, haemophilia A, magnetic resonance imaging score, musculoskeletal, Pettersson score
Abstract:
. The functional independence score in haemophilia (FISH) is a performance-based instrument used to assess musculoskeletal function in patients with haemophilia. We aimed to evaluate the functional independence of haemophilia A adolescents and its correlation to radiological joint scores. A cross-sectional study was carried out on 50 adolescent haemophilia A patients. Musculoskeletal function was assessed using the FISH and individual joints were assessed radiologically using the Pettersson score and MRI scale. The mean age of our patients was 16 +/- 1.1 with a mean FISH of 23.32 +/- 4.69 (range 1328) and a mean Pettersson score of 2.32 +/- 3.09 (range 013) for the knees, 1.86 +/- 2.67 (range 011) for ankles and 1.42 +/- 2.17 (range 010) for elbows. The mean MRI score for the knees was 3.92 +/- 2.74 (range 010) while that for ankles was 3.16 +/- 2.64 (range 010) and for elbows was 2.34 +/- 2.63 (range 010). There was highly significant correlation between both radiological joint scores and FISH and between degree of factor VIII deficiency and each of FISH, Pettersson score and MRI score. MRI was superior to conventional radiography in detection of subchondral cyst formation and erosions at joint margins. Given the highly significant correlation with both radiological joint scores, FISH appears to be a reliable tool for assessment of functional independence in adolescents with haemophilia A. MRI is more sensitive than conventional radiography in detection of early joint abnormalities.
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