a neurotoxicologic evaluation or spinal

differences clearly exist between man and rabbit in terms ofanatomy, methods of performing spinal anaesthesia, and dosage andvolumes of anaesthetic solutions. Despite these differences, it wouldappear that the present model is capable of predicting neurotoxicityanaesthetic drugs on the spinal cord that comparable to thoseobserved in man.This experimental work was conducted on twenty five New-Zealand rabbits of either sex of varying weights range between2,200-2,300 kg.The animals were divided into five groups each divided intotwo sub group CA) and CB) . Subgroup A in which animals werereceived single injection and scarified on the 6 th day, and subgroup(B) in which animals received repeated injection and scarified on the14 th day.Group 1: received saline 0.9%.spinally.Group 2: received 1% lidocaine spinally .Group 3:. received 1mg/ kg ketamine spinally.Group 4:. received 0.1 % midazolam spinally.Group 5: received O.3ugl kg clonidine spinally/