Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:1- The nature of the initial physeal injury.2- If the physeal injury is open or closed.3- The location of the cleavage plane through the zones of the epiphyseal pate.4- The anatomical location of the epiphyseal fracture.5- The adequeacy of the treatment of recent epiphyseal injury.6- The patient age at the time of injury e.g. partial or complete epiphyseal arrest in the young child provides a far greater problem than that in the adolescent.The methods of treatment of sequele of epiphyseal injuries are very important includes:1-Treatment of partial growth arrest by osseous bridge resection and implant but failure of the technique may occur, producing erbridging.2- Correction of the angular deformity by osteotomy or epiphyseal stapling.3- Epiphyseal distraction either asymmetrical distraction in angular deformity or symmetrical distraction in complete epiphyseal arrest.4- Epiphyseal transplantation either with or without blood supply the results are only experimental and have no specific indications for use except when a growth center is completely lost with the injury.Summary and conclusionFor management of neglected epiphyseal injuries fundamental points must be clarified:Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.Automated blood culture systems as vital system and the vitek system for easily and rapid identification of organism. We found that staph-aureus was the organism isolated from (63.3 % ) of cases but all control were staph-aureus negative.Identification of MRSA isolates was done by BBL crystal MRSA identification system; we found that all cases (63.3 %) of blood culture positive to staph-aureus were MRSA.Our study shown that (63.3 %) of the cases had MRSA from which (31.6 %) were manifested by NTED. measurement of anti-TSST-1Ab?s by ELISA shown that; The anti-TSST-1 IgG titer in NTED were less than (0.2 OD at 450 nm.) the anti-TSST-1 IgG titer in carriers between (0.18 to 0.3 OD at 450 nm.) and the anti-TSST-1 IgG titer in Controls more than (0.2 OD at 450 nm.).Also we found that; The anti-TSST-1 IgM titer was negligible (less than 0.01) soon after birth (4-7 days) in all NTED, carriers and controls, but at one month of life, the anti-TSST-1 IgM Ab titer had increased in recovery neonates (from 0.01 - 0.03)the extracted DNA were amplified by PCR analysis of the amplified product by a garose gel electrophoresis for detection the mec A gene MRSA. We found that mec A gene was presented in (53.3 %) neonates had MRSA.Conclusion- NTED was found in Neonatology Unit of Pediatrics Department, Zagazig University Hospital. It represented (31.6 %) from all cases of MRSA (63.3 %) from August 2002 – August 2004.- MRSA was the causative organism of NTED.- Mec A gene was present in most cases had MRSA positive carriers; so Mec A gene was the cause of high level resistance to methicillin.- Anti-TSST-1 Ab?s transferred placentally from the pregnant women to her baby play a role in protecting neonates from developing NTED.Summary and conclusionNeonatal toxic shock syndrome like exanthematous disease (NTED) is a new neonatal disease caused by toxic shock syndrome toxin-1 (TSST-1). It has the following clinical criteria (i) exanthema plus (ii) at least one of the following three signs: thrombocytopenia (low platellat count < 150.000/mm3), a low – positive serum CRP value (positive CRP > 1.0 mg/dL) and fever (rectal temperature of > 38oC)Since 1992; the number of hospitals in Japan in which this disease had been encountered increased from 25.7 % in 1995 to 70.8 % in 1998. subsequently, microbiological examination showed that most of the neonates with this illness were colonized by methicillin-resistant staph-aureus (MRSA) strains that produced TSST-1. also NTED appeared in France in 2002 and Netherlands in 2003. there the apprehension that NTED will become widespread throughout the world.To Study the prevalence of neonatal toxic shock syndrome like exanthematous disease (NTED) in our Neonatology Unit of Pediatric Department, Zagazig University Hospital, identification the causative organism of this disease and the preventation.This study was conducted from August 2002 to August 2004.The study included two groups :(1) Cases:This study included 30 neonates within the first week of life, from which 10 neonates with rash but other 20 neonates without rash. The cases were selected from Neonatology unit of pediatric Department, Zagazig university Hospital .(2) Controls group :Included 15 healthy neonate within The first week of life (except the recovery cases) selected from obstetric unit of obstetric and Gynecology Department, Zagagzig University and from neonates seeking medical Advice at The outpatient clinic of pediatrics, Zagazig university Hospital.Swabs and blood samples were collected from all cases and controls were tested by:• Nasal swabs, bacterial isolation and identification• Conventional blood culture• Mini vital automated system• Vitek• System identification MRSA BBL crystal• Measurement of anti-TSS-1 Ab?s by Elisa• PCRNasal swabs and blood samples were taken from all cases and controls and isolated on blood agar and mannitol salt plates identification of staph. aureus isolates was done by microscopically examination (catalase test, coagulase test and urease test). The results showed that (73.3%) of cases were positive to staph-aureus compared with (6.7%) of controls.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.SUMMARYThere is growing interest in QT dispersion as a marker for arrhythmia potential being a marker of inhomogenicity of ventricular repolarization. The QT dispersion is increased in myocardial ischemia and infarction, and levels are higher in patients with ventricular arrhythmias. This study was performed to assess QT dispersion in patients with acute myocardial infarction treated with thrombolytic therapy with successful reperfusion versus those who treated with thrombolytic therapy with failed reperfusion and those who treated with conventional therapy and to correlate between QT dispersion and the complicating serious ventricular arrhythmias following acute myocardial infarction. And it is also performed to assess the influence of age, sex, obesity, smoking, diabetes mellitus, hypertension and site of infarction on QT dispersion. The study included 100 patients with recent acute myocardial infarction and they are classified to 3 groups:Group 1: 30 patients who received streptokinase with successful reperfusion.Group 2: 30 patients who received streptokinase with failed reperfusion.Group 3: 40 patients who did not receive streptokinase (control group).Every patient was subjected to full history taking and thorough clinical examination. Analysis of serum electrolytes (Na, K and ca) was done and cases showing abnormal results were excluded. Serum CPK was checked on admission, after 6 hours, after 12 hours and after 24 hours after onset of thrombolytic therapy. ECG was done for every patient on admission, two hours post thrombolytic therapy and predischarge in groups I and 2. In group 3, ECG was done on admission and predischarge.The study concluded that:1- There is a statistically significant reduction in QT dispersion in patients who received thrombolytic therapy with successful reperfusion versus those who received thrombolytic therapy with failed reperfusion and those who did not receive thrombolytic therapy.2- There is a reduction in the incidence of ventricular arrhythmias in patients with successful reperfusion therapy associated with the reduction in the QT dispersion. So, reduction of QT dispersion may be a mechanism of benefit of thrombolytic therapy.3- QT dispersion is increased after myocardial infarction and levels are higher in patients with ventricular arrhythmias.4- QT dispersion is influenced by hypertension, diabetes mellitus, age and site of infarction ,as it is increased in patients with hypertension, diabetes mellitus, age less than 50 years and with anterior than inferior infarction.The study recommended the following:1- Whenever not contraindicated, thrombolytic therapy should be administered as early as possible in cases with AMI.2- QT dispersion can predict the potential for ventricular arrhythmias in patients with AMI.3- Future studies are needed to confirm the value of QT dispersion in risk stratification after AMI.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.Regarding neonatal outcome of studied groups, patients with a negative amniotic fluid culture but positive PCR (group 2) had a significantly higher rate of adverse outcome including low gestational age at birth, low birth weight, and significant neonatal morbidity than those with a negative amniotic fluid culture and negative PCR (group 1). However, no differences were found between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture regardless the results of PCR (group 3).SUMMARYPreterm premature rupture of membrane occurs in 3% of pregnancies and is responsible for approximately one-third of all preterm births.Preterm PROM is an important cause of perinatal morbidity and mortality.Recent studies suggest an association between Intrauterine infection and both preterm delivery and morbidity of preterm infant. U. Urealyticum is the microorganism most frequently isolated from amniotic fluid of women with preterm labour and PROM.U. urealyticum has been implicated in the genesis of clinical chorioamnioitis, puerperal endometritis, neonatal sepsis and bronchopulmonary dysplasia (chronic lung disease).U. urealyticum isolation in clinical specimens remains a challenge, microbial culture for this organism require special culture conditions and results are generally not availably in time for clinical management decisions.Recently PCR has became an optimal method for the rapid detection of U. urealyticum in clinical specimen.The aim of our study was to determine the frequency and clinical significance for the detection of U. urealyticum in patients with preterm premature rupture of membranes.Our study included 100 patients with preterm premature rupture of membranes with gestational age less than 35 weeks and singleton gestation.Patients participated in our study underwent full history taking and clinical examination.Amniotic fluid was collected by transabdominal amniocentesis guided by ultrasonography and was immediately examined for WBC,s count and sent for microbiologic culture. An aliquot of fluid was stored at -70°C for PCR examination.According to the results of amniotic fluid cultures and PCR for U. urealyticum patients divided into 3 groups:o Group 1: (n.=59) Those with a negative amniotic fluid culture and a negative PCR assay.o Group 2 (n.=15): Those with a negative amniotic fluid culture but a positive PCR for Ureaplasma urealyticum.o Group 3 (n.=26): Those with a positive amniotic fluid culture for microorganisms regardless of the results of PCR.Regarding maternal age of the studied groups, There was no significant differences in the mean age at amniocentesis among the 3 group of patients.The difference in the gestational age at amniocentesis among the 3 groups of patients was not statistically significant, however patients with a positive amniotic fluid culture regardless PCR (group 3) showed the lowest mean gestational age at amniocentesis among the 3 studied groups.Patients with a negative amniotic fluid culture but a positive PCR (group 2) had a significantly higher amniotic fluid white blood cell count than those with a negative amniotic fluid culture and a negative PCR. However, there was no significant difference in the amniotic fluid white blood cell count between patients with a negative amniotic fluid culture but positive PCR and those with a positive amniotic fluid culture.The three studied groups regarding clinical chorioamnionitis revealed no statistically significant difference.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.Summary and conclusionThe aim of this study is to assess the accuracy of magnetic resonance imaging versus computed tomography in diagnosis of nasopharyngeal mass.This study was done during the period from June 2002 to December 2003 in Radiology Departments, Zagazig University Hospitals. The study included 30 patients, 19 males and 11 females, their ages ranged from 5 to 69 years.The patients were subjected to:1- Clinical examination.2- CT scanning.3- MRI4- Histopathological analysis.The lesions encountered in our study were classified into 22 malignant lesions and 8 of benign nature.The malignant lesions were further subdivided into tumors arised from the nasopharynx itself, they were squamous cell carcinoma in 12 patients, lymphoma in 8 patients, and malignant tumors extended to the nasopharynx in the form of chordoma and carcinoma of the maxillary sinus.Eight patients with benign lesions were included in our series, further subdivided into 6 cases arised from the nasopharynx, they were 3 cases of angiofibroma, 3 cases of adenoids, or direct extension from adjacent structures in two cases, one case of nasal angiofibroma and the other was pleomorphic adenoma of the deep part of the parotid gland.Both CT and MRI were done for all our patients, CT was effective in the determination of the lesion, extension, other close association, the bone destruction and abnormal calcifications inside the tumor, however CT failed to distinguish between the tumor itself and the surrounding soft tissue structures.MRI is a sensitive technique in good differentiation between the tumor itself and the surrounding structures, the extension and the obliteration of the surrounding spaces, MRI has also good advantages of determination of the intracranial extension.In conclusion:The Computed Tomography is effective in imaging of the nasopharyngeal lesions as if they are primarily arise from or as an extension from the parapharyngeal structures. It also provides a good details about the nature of the lesion, density, extension and other association and presence of calcifications or bone destruction, which is deficient in MR imaging.The advantages of MR imaging with its superior soft tissue contrast resolution, absence of bone hardening artifacts, and ability to image in multiplanner fashion has allowed to image the deep fascial structures as well as the distinction between the tumor and the surrounding soft tissue is easier than that of computed tomography.So both CT and MRI are well-established methods in diagnosing diseases of the nasopharynx and its surrounding.The recommended diagnostic strategy for mass lesions of the nasopharynx and surrounding structures is to use Gd-enhanced MRI as a primary study and contrast enhanced CT as a secondary study for the evaluation of fine bony details.