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Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
67-72
Authors:
Mohamed, Rasha H, Pasha, Heba F, EI-Shahawy, Eman E
DOI:
10.1016/j.cellimm.2011.11.005
Journal:
CELLULAR IMMUNOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
Volume:
273
Research Area:
Cell Biology; Immunology
ISSN
ISI:000299862700009
Keywords :
Rheumatoid arthritis, TRAF1/C5, STAT, Polymorphism, Egyptian population
Abstract:
Rheumatoid arthritis (RA) is the most common cause of adult inflammatory arthritis. Recent genome-wide association scans have disclosed several single-nucleotide polymorphisms associated with RA susceptibility. The aim of this study was to determine whether the polymorphisms of TRAF1/C5 (tumor necrosis factor (TNF)-receptor associated factor 1)/(complement component 5) and STAT4 (signal transducers and activators of transcription 4) confer susceptibility, activity and severity to RA in Egyptian populations. One hundred and seventy-two RA patients and 160 controls were enrolled in the study. Polymorphisms of TRAF1/C5 and STAT4 genes were determined using restriction fragment length polymorphism-polymerase chain reaction. The TRAF1/C5 A and STAT4 T alleles were significantly associated with RA in Egyptian population. TRAF1/C5 A allele and STAT4 IT genotype were significantly associated with RA severity. In conclusion the mutant alleles or genotypes of both examined polymorphisms are associated with the development of RA in Egyptian population. (C) 2011 Elsevier Inc. All rights reserved.
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