| Abstract: |
this work was done on 20 patients, 11 females and 9 males, whomunderwent elective open heart surgery in Cardiothoracic SurgeryDepartment, Zagazig University Hospital, for repair or replacement ofrheumatic valvular heart diseases or repair of congenital atrial septaldefects. The aim of this work was to study the effect of cardiopulmonarybypass on the haemostasis and to correlate the post bypass bleeding tothese changes in haemostatic parameters. Cardiopulmonary bypass (CPB)was used for all patients for a period of time ranging between 50 and 200minues with a mean value of 139.8±43.8 minutes.The following haemostatic parameters were studied for each patient;platelet count, mean platelet volume, platelet aggregation with ADP,bleeding time, prothrombin time, activated partial thromboplastin time,time, activated clotting time and fibrinlogen degradationThese haemostatic parameters were detected at 3 different timesfor each patient (1) preoperative-base line-after induction of anaesthesiaand insertion of central venous lines, (2) postbypass, 15 minutes afterreversal of heparin with protamine sulphate, and (3) postoperative, 18urs after the end of the operation. Indeed, all haemostatic parametersd had been significantly affected by CPB.Paletelet count, mean platelet volume, platelet aggregation withP and bleeding time were significantly affected with CPB procedurethe degree of affection were correlated with the time of the bypass.
|
|
|