Otoprotective effect of lipoic acid against cisplatin ototoxicity in human

Cisplatin induced ototoxicity is related to impairment of cochlear antioxidant defense system which is formed of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-Px), Glutathione Reductase (GR), increase in Malondialdehyde (MDA) (Ryback et al., 1999).Ototoxicity is normally irreversible, bilateral, sensorineural and affects mainly the frequencies from 4-8 kHz (Blakley et al., 1994).Accumulated dose (Brock et al.,1991) and bolus administration (Strauss et al., 1983) are factors that aggravating ototoxicity.