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Spectrofluorimetric Determination of Etodolac, Moxepril HCl and Fexofenadine HCl Using Europium Sensitized Fluorescence in Bulk and Pharmaceutical Preparations
Faculty
Pharmacy
Year:
2012
Type of Publication:
Article
Pages:
247-252
Authors:
Abd El-Hay, Soad S, Colyer, Christa L, Hassan, Wafaa S, Shalaby, Abdalla
DOI:
10.1007/s10895-011-0954-8
Journal:
JOURNAL OF FLUORESCENCE SPRINGER/PLENUM PUBLISHERS
Volume:
22
Research Area:
Biochemistry \& Molecular Biology; Chemistry
ISSN
ISI:000302463100026
Keywords :
Sensitized fluorescence, Europium, Etodolac, Moxepril HCl, Fexofenadine HCl
Abstract:
A simple, selective and sensitive luminescence method has been developed for the assay of etodolac (I), moxepril HCl (II) and fexofenadine HCl (III) in bulk drug and pharmaceutical formulations. The method is based on the luminescence sensitization of europium (Eu3+) by complexation with the studied drugs. The fluorescence intensities of the products were measured at 667 nm for (I) and at 615 for (II) and (III) while exciting at 276 for all the studied drugs. The fluorescence intensity was directly proportional to the concentration over the range (20-280), (40-240) and (30-80) ng/ml with limits of detection (LOD)=0.93, 0.92 and 0.95 mu g/ml for drugs I, II and III respectively. Optimum conditions for the formation of the complex in methanol were carefully studied. The proposed method was successfully applied for the assay of the studied drugs in pharmaceutical formulations with excellent recovery.
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