Traceless chemical ligations from O-acyl serine sites

Faculty Pharmacy Year: 2012
Type of Publication: Article Pages: 4836-4838
Authors:
El-Feky, Said A, Katritzky, Alan R, Asiri, Abdullah, Elagawany, Mohamed, El Khatib, Mirna, Khelashvili, Levan, Jabeen, Farukh, Todadze, Ekaterina, Bol'shakov, Oleg, Oliferenko, Alexander
DOI: 10.1039/c2ob07050b
Journal: ORGANIC \& BIOMOLECULAR CHEMISTRY ROYAL SOC CHEMISTRY Volume: 10
Research Area: Chemistry ISSN ISI:000304885200002
Keywords : Traceless chemical ligations from O-acyl serine    
Abstract:
Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.
    
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