Immunophenotyping of lymphocytes in atopic dermatitis

The aim of this work was to study the immunophenotyping of lymphocytes in atopic dermatitis in a trial to find out the underlying immunological mechanism of such allergic disorder. Correlation of such lymphocyte subsets with the disease activity and severity of the condition is another aim of this study. The results revealed a significant positive correlation between IgE and the percentage of B- lymphocyte CD19^+, T-helper cells CD4^+ and CD4^+ / CD8^+ ratio. There was a significant negative correlation between IgE and the percentage of total T-lymphocyte (CD3^+), T-suppressor cells CD8^+, and NK cells (CD16^+, CD56^+). There was no significant correlation between IgE and either lymphocyte percentage, absolute lymphocytic count or activated T-cells (CD3^+ / HLA-DR).