Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Usefulness of Helicobacter Pylori Eradication for Platelet Recovery in Egyptian Idiopathic Thrombocytopenic Purpura Patients
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
825-829
Authors:
Mohamed, Hanan E, Akl, Hosneia Kh, El-Hady, Hoda A
Journal:
LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION MARSLAND PRESS
Volume:
9
Research Area:
Life Sciences \& Biomedicine - Other Topics
ISSN
ISI:000306398400119
Keywords :
H. pylori, eradication therapy, platelet count, immune thrombocytopenic purpura
Abstract:
Background: Recent studies have shown a relationship between Helicobacter pylori (H. pylori) and idiopathic thrombocytopenic purpura(ITP). Objectives: To clarify the relation between H. pylori and ITP, determine its prevalence in this disease and to evaluate the effect of its eradication on platelet recovery. Subjects and methods: 65 adult patients with ITP (platelet count < 100 x 10(3)/mu l) were investigated for the presence of H. pylori infection and its eradication by H pylori stool antigen (HpSA) enzyme immunoassay method (EIA). H. pylori positive patients received standard triple therapy for seven days to eradicate infection. Platelet counts were monitored every 2 weeks and assessed 6 months after the end of H. pylori eradication therapy. Uninfected patients underwent immunosuppressive therapy and their platelet counts were followed up for the same duration. Results: 45/ 65 ITP patients, were H. pylori positive. They were significantly older and showed longer disease duration than H. pylori negative patients. There was significant increase in platelet count in both group after treatment and this increase was significantly higher in H. pylori positive group than negative one. Out of the 45 infected patients who received treatment, H. pylori was successfully eradicated in 39 patients. In 21 (53.8\%) of these patients, significant good platelet response was detected when compared with unsuccessfully treated and H. pylori negative patients. Conclusion: Eradication of H. pylori infection led to good platelet response in ITP patients. Therefore, search for this infection must be attempted in ITP patients at diagnosis which will allow a good non immunosuppressive option for some of them. {[}Hosneia Kh. Akl, Hanan E. Mohamed, Hoda A. El-Hady Usefulness of Helicobacter Pylori Eradication for Platelet Recovery in Egyptian Idiopathic Thrombocytopenic Purpura Patients] Life Science Journal 2012; 9(1):825-829]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 119
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف