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BUCCOADHESIVE TABLETS FOR DELIVERY OF VERAPAMIL HCl: DESIGN, IN-VITRO ANALYSIS AND IN-VIVO EVALUATION
Faculty
Pharmacy
Year:
2012
Type of Publication:
Article
Pages:
17-25
Authors:
Ghazy, Fakhr El Din S, El-Nahas, Hanan M, Gad, Mohamed A, Eissa, Noura G
Journal:
BULLETIN OF PHARMACEUTICAL SCIENCES ASSIUT UNIV, FAC PHARMACY
Volume:
35
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000310183400002
Keywords :
BUCCOADHESIVE TABLETS , DELIVERY , VERAPAMIL HCl: DESIGN,
Abstract:
Buccoadhesive controlled release verapamil HCl tablets have been prepared using mucoadhesive polymers namely; sodium alginate (Na Alg), xanthan gum (XG) and gum tragacanth (GT) either alone or in combination in different ratios 2:8, 8:2, 4:6 and 6:4. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and in-vivo hypertension study. Tablets containing XG showed the highest swelling index and bioadhesive force. The maximum cumulative \% released (100\%) was observed in F7, F10 and F11 due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except F1 that it obeyes a diffusion model. The buccoadhesive verapamil HCl tablet had suggested being promising for the transmucosal delivery of verapamil HCl and allowing a controlled drug delivery for 6 hrs.
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