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Tracking Genes Modifications in the Pedigree Through GeneTracer Algorithm
Faculty
Science
Year:
2012
Type of Publication:
InProcceding
Pages:
Authors:
Alzohairy, Ahmed Mansour, Issa, Mohamed, Bakr, Hitham Mohamed Abo, Ziedan, Ibrahim Elsayed
Journal:
IEEE COMPUTER SOC
Volume:
Research Area:
Computer Science
ISSN
ISI:000312658400038
Keywords :
Pairwise local alignment, Tracing genes modifications algorithm
Abstract:
Genes acquire many changes and modifications during evolution producing many orthologous and paralogous. One of the main challenges for biologist is tracing back the origin of modified genes in the genomes of various organisms. Tracing genes modifications and developments from the ancestors to offsprings is however a massive task for biologists. Thus, computer programs can help biologists tracking down those changes through sequence alignment. In this paper, we present an algorithm, called GeneTracer and based on sequence alignment, that, given two ancestor sequences and their offspring one, tracks down genes modification in the ancestor sequences and finds related parts of each ancestor in the offspring one.
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