Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Application of brominating agents and potassium dichromate for the spectrophotometric determination of captopril in pharmaceutical formulations
Faculty
Science
Year:
2012
Type of Publication:
Article
Pages:
285-297
Authors:
El-Didamony, Akram M
DOI:
10.3233/MGC-120081
Journal:
MAIN GROUP CHEMISTRY IOS PRESS
Volume:
11
Research Area:
Chemistry
ISSN
ISI:000313844800005
Keywords :
Bromate-bromide mixture, potassium dichromate, redox reactions, spectrophotometry, captopril, pharmaceutical formulations
Abstract:
Three simple and sensitive spectrophotometric methods were developed for the estimation of captopril (CAPT) in pure form or in tablet formulations. The three methods are based on the reactivity of the thiol group. The first two methods (A and B) are based on the oxidation of CAPT by bromate/bromide mixture of known concentration in acid medium. In method A, the determination of the residual bromine is based on its ability to bleach the methylene blue dye and measuring the absorbance at 664 nm. Method B involves treating the unreacted bromine with a measured excess of iron(11) and the remaining iron(11) is complexed with 2,2'-dipyridyl and the increase in absorbance is measured at 523 nm. Method C involves the addition of a known excess amount of potassium dichromate in acidic medium, followed by the estimation of unreacted amount of dichromate by reacting with excess of iron(II). The resulting iron(III) is complexed with thiocyanate and the absorbance is measured at 478 nm. In all the methods, the amount of oxidant reacted corresponds to the drug content. The different experimental parameters affecting the development and stability of the color product are carefully studied and optimized. After validation, the proposed methods were successfully applied to assay of CAPT in its commercial tablets. No interference was observed from common additives found in pharmaceutical preparations. The results were statistically compared with those of a reference method by applying Student's t- and F-test.
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف