Improved anti-inflammatory effect of Silymarin in rats induced liver carcinogenesis

In the present work the protective role of silymarin in rats-induced liver carcinogenesis was studied. Twenty eight male albino rats were randomly assigned to five groups: Group A; served as control, (Group B); HCC-induced group, Group C; HCC-induced group and treated with silymarin for 2 weeks and (Group D); HCC-induced group and treated with silymarin 2 weeks before induction the carcinogenesis and 2 weeks after induction of carcinogenesis. HCC -induced rats were treated with an oral dose of 20 mg/kg of DENA. Rats treated with silymarin received a daily single dose of (40 mg/kg body weight) suspended in saline by gavages. Blood samples were collected for determination of ALT, AST, bilirubin, AFP, IL-2 and IL-6 in serum, liver samples were collected for studying the gene expression of IL-2, IL- 6 and GAPDH and histopathological examination. Our results demonstrated that ALT, AST, bilirubin levels were significantly lower in silymarin treated groups if compared with non treated HCC-induced rats. Circulating AFP, IL-2\&6 were significantly low in silymarin treated groups if compared with HCC-induced rats. The expression level of IL-6 showed the highest expression level in non treated HCC-induced rats with high expression level of IL-2 in control groups. In conclusion silymarin improve the anti-inflammatory status in HCC-induced rats. {[}Ali Alkaladi and Aser Mohamed Abdelazim. Improved anti-inflammatory effect of Silymarin in rats induced liver carcinogenesis. Life Sci J 2012;9(4):2865-2869] (ISSN:1097-8135). http://www.lifesciencesite.com. 420