Role Of Apoptosis In Different Renal Diseases In Pediatrics

Apoptosis refers to energy-dependent cell death in which individualcells participate in their own fragmentation and deletion from living tissue.It is a natural and active process in normal and neoplastic tissues.The aim of this work was to study the role and regulation ofapoptosis in different renal diseases that may improve our knowledge ofthemode of action of current therapies, and it may also provide the basis forthe design ofnew therapeutic strategies.This study was conducted on 80 children attending the pediatricNephrology and dialysis unit of pediatric department, Zagazig UniversityHospital.They were divided into ”4” groups:Group (1): (20 cases)(a) Includes 10 cases (4 males and 6 females) suffering from chronic renalin sufficiency (CRI) and treated conservatively, their age ranged from(3-13) years with mean value of8.15±3.83 years.(b) Includes 10 cases (4 males and 6 females) suffering from end stagerenal diseases (ESRD) and on regular hemodialysis their age rangesfrom (4-17 years) with mean value of 11.8±4.492 years in addition toconservative management, regular hemodialysis was conducted for 3-4hr/session, 3 times a week, of single pass acetate hemodialysis, at ablood flow rate through double needle system of 125 mllmin anddialysate flow (Qo) of 500 rnl/min.During each session, high molecular weight heparin (50 Iu/Kg bodyweight) was administered to prevent coagulation.154- Hollow fiber poly sulfone dialyzer (fesenius medical care AG) werechosen according to the individual needs of the patients.- Measurement of serum lNFcx. and CD9S was done just before dialysissession and just after it.