SUMMARY AND CONCLUSION(I) DHEA treated group:After 2 months of daily DHEA administration in adult female rats, the mean value of the mitotic count was (3.250 ± 2.085) which progressed after 4 months to (4.640 ± 2.650) then regressed after 6 months (2 months follow up without treatment) to (3.591 ± 1.57).In senile group, with daily administration of DHEA, the mean value of the mitotic count in breast cells was (1.828 ± 0.599) which progressed after 4 months to (3.645 ± 1.476) then regressed after 6 months (2 months follow up without treatment) to (2.025 ± 0.542).(II) Combined DHEA and vitamin E treated group:After 2 months of daily DHEA with vitamin E administration, the mean value of the mitotic count was (2.925 ± 0.547) which progressed after 4 months (4.020 ± 2.986) then regressed to (3.039 ± 0.396) after the follow up period.In senile group taking this combined therapy, no significant difference in the mean value between the three periods of the study. The mean value of the mitotic count was (1.656 ± 0.590) after 2 months, (1.619 ± 0.707) after 4 months and (1.661 ± 0.372) after cessation of the drugs.Effect Of SkinThe mean values of the mitotic count were within normal values throughout the whole periods of the study in both adult and senile female albino rats either taking DHEA or combined DHEA and vitamin E.CONCLUSION(1) The effect of DHEA in liver of senile rats is more hazardous than in liver of adult rats.(2) Dehydroepiandrosterone (DHEA) as a precursor for sex hormone had toxic effects on organs under hormonal control like ovary and breast which were more obvious in adult than in senile female albino rats especially with prolonged administration of high doses.(3) When DHEA was stopped for 2 months as a follow up period, a regression was detected in liver congestion and inflammation of both adult and senile female rats, also there was a regression in glandular hyperplasia of breast tissue of both adult and senile female albino rats. But no regression was detected in the toxic effects of DHEA regarding HCC and polycystic ovaries in both adult and senile female albino rats.(4) Vitamin E protected the liver against the effect of DHEA induced toxic capillarites (congestion and inflammation). However, it did not protect liver against hepatocellular carcinoma in both adult and senile female albino rats.(5) Vitamin E had no protective role in DHEA induced polycystic ovaries (PCO) in both adult and senile female albino rats.(6) Vitamin E protected the breast tissue against DHEA induced glandular hyperplasia only in senile female albino rats.(7) DHEA had a real benefit effects on the skin of senile female rats through improving the thickness of the skin as well as the size and number of the sebaceous glands.(8) Concerning skin improvement by DHEA administration, there was a regression in the improved sebaceous glands when DHEA was stopped for 2 months as a follow up period.(9) Vitamin E augmented the effect of DHEA on the skin of senile female rats by increasing the skin thickening and the size and number of the sebaceous glands. Also, preserve the size and number of these glands even after cessation of combined DHEA and vitamin E.(10) AgNORs stained slides estimated by Computerized Analyzer System 200 (CAS 200) was an early and sensitive indicator for cell proliferation which observed in the histophatological picture.