Study of serum vascylar endothelial growth factor and vascular cell adhesion molecule in metasttic breast cancer and response to weekly docetaxel protocol

This study aimed to assess the efficacy and tOXICIty of weeklydocetaxel at a dose of 36mglm2, also to evaluate serum VEGF and serum.,’i VCAM -1 as markers of response to this protocol in metastatic breastcancer who failed anthracycline pre-treatment. Forty female patients withmetastatic breast cancer were included in this study and all patients weresubjected to history, clinical examination, routine laboratory investigations,radiological studies and evaluation of S-VEGF and S-YCAM-I by ELIZA.All patients were treated with docetaxel 36mg/m2 for successive 6weeks followed by 2 weeks rest of treatment (one cycle). Patients wereevaluated for response after one cycle (8 weeks) and responding patientscontinued for 32 weeks (4 cycles) then response and toxicity wereevaluated.