Study The Effect Of Somatostatin And Gastrin Hormones On Esophageal Motility And Gastroeaophageal Refluxin Cirrhotic Patients

Disturbance of esophageal motility and gastroesophageal refluxdiseases are commonly encountered in cirrhotic patients and have beensuggested to be responsible for upper digestive symptoms and a pathologicalgastric acid reflux. Gastroesophageal reflux disease and esophagealdysmotility in cirrhotic cases have been shown to be influenced for greatinstance by the level of gastrointestinal hormones in the senun and itsdisturbance may lead to the appearance of digestive complaints in cirrhoticpatients.So, this work evaluated the plasma concentrations of gastrin andsomatostatin hormones in compensated liver cirrhotic patients aiming atfinding any relation of both hormones and their impact on the occurrence ofesophageal motility disorders, and gastroesophageal reflux in such patientsThis work had been conducted in Tropical Medicine Department andBiochemistry Department, Zagazig University Hospital, and performed ontwo groups:”, First group (patients’ group): 40 patients with compensated livercirrhosis associated with dyspepsia after exclusion of other diseases thataffects gastrointestinal motilitySecond group (control group): 20 individuals with dyspepsia and notsuffer from other diseases.SlJllltI101:V mid COIlc/US(nl1I i(OJBoth groupswere subjected to:~ Full history taking,~ thorough clinical examination (exclude pregnancy, ascites)- Laboratory investigation, such as liver and kidney function tests toexclude advanced diseases and diseases that affect esophageal motilitysuch as diabetes mellitus, thyrotoxicosis, gall bladder diseases,- Electrocardiography (ECG) to exclude cardiac disease as a cause ofchest pain.~ Abdominal ultrasonography and upper GIT endoscopy.,~ Liver biopsy to confirm diagnosis of cirrhosis.- Esophageal motility study and ambulatory 24 hours pll monitoring.- Serum gastrin and somatostatin concentrations were determinedradioimmunologically after overnight fast.