Itching in skin and some systemic diseases

Itching i s the most puzzling of cutaneous sensations the most challenging problems in clinical practice 1987 itch lS no longer considered to nd new evidence shows that there are and fibers for pain and itch be subthreshold pa in different subsets of Torebjork and Ochoa Histamine lS the classical peripheral itch mediator ich induces a ”true” itch when injected intradermally and to play an essential role i n the pathogenesis But ln some pruritic diseases nothing is known lout mediators or other pathogenic mechanisms involved. Recently, histamine release enhancing factors have been It is a cytokin which can produced from a vareiety Baeza et al., 1988)Grattan(1990)demonstrated a serological histamine releasing factor in chronic urticaria with properties like nIgE auto-antibody.