Ototoxigity of ethaornic Acid Edecrin

Summary conolusion Ethacrynic acid is a kltomototoxic drug. A lot of work proving its ototoxicity is published in tho liter - ature but with some contraversy between some of the authors. This work tried to demone st r rrte the toxic effect of ethacrynic and to show the exact cochlear chang es pothological, phys1dogical, histochemic el J enzymatic,electrolytics, electrical potenlials, central evoked response That took place following ethacrynic acid n histol. changes not ed in guinea pig were edema I the atria vasoularis nth cyst formation but lith normal marginal .ecUate and inner eellaOf the stria_ The organ of corti sho-ved outer hair oel1 loss with no:nnal inner cel’ls f supporting cells and gang- lion oells. J these changes occur-e d in the b aa a’l, turn of the ohoch1ea (Matz,1976) Effect of e thacrynic acid on the electrolytes of endolymphatic and perilympha1c. system of the cochlea.