Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Association of Interleukin-18 with Sustained Virological Response (SVR) To Interferon Therapy in Patients with Chronic Liver Diseases
Faculty
Science
Year:
2012
Type of Publication:
Article
Pages:
4542-4550
Authors:
Mohamed, Waleed S, Loutfy, Samah A, Mohamed, Amal A, Amer, Marwa
Journal:
LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION MARSLAND PRESS
Volume:
9
Research Area:
Life Sciences \& Biomedicine - Other Topics
ISSN
ISI:000316686000058
Keywords :
Hepatitis C virus (HCV), Antiviral therapy (interferon, ribavirin), Interleukin-18 (IL-18)
Abstract:
Background: Pegylated interferon plus ribavirin is the standard therapy for treatment of Chronic hepatitis C (CHC) patients, this therapy is only effective in 50-60\% of infected individuals. Pretreatment predictors associated with sustained virological response (SVR) to interferon treatment have not yet been fully investigated. Several factors have been shown to influence response to antiviral treatment, one of them is interleukin - 18 (IL-18). There are few data on IL-18 in relation to infectious diseases, but it plays a prominent role in chronic HCV infection. Thus, the current study is designated to assess serum Interleukin -18 levels in CHC genotype 4 patients and its association with treatment response. Patients and Methods: This study was performed on fifty Egyptian chronic hepatitis C patients, who received combined pegylated interferon alpha and ribavirin therapy and twenty healthy blood donors as a control group. Quantitative hepatitis C virus RNA was done by real time RT-PCR technique. Serum IL-18 level was assayed using quantitative ELISA plate method. Results: The mean level of IL-18 was significantly higher in CHC patients (212.15 Pg/ml) compared to the controls (48.95 Pg/ml). IL-18 level in responders was significantly reduced after 6 months from the end of treatment compared to those at baseline level (P=0.001), but such decrease was lower than that in non responders (P= 0.058). IL-18 level was positively correlated with high and moderate viral load in non responders. Conclusions: Serum IL-18 level has the potential to be used as a biological marker to predict outcome of antiviral therapy among CHC genotype 4 patients. {[}Waleed S. Mohamed, Samah A. Loutfy, Amal A. Mohamed and Marwa Amer. Association of Interleukin-18 with Sustained Virological Response (SVR) To Interferon Therapy in Patients with Chronic Liver Diseases. Life Sci J 2012; 9(4): 4542-4550]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 681
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف