Effect of Storage of Blood

the sequential changes of fibrinogen which occur duringtorage of blood in ACD anticoagulnnt preservative for 21 daysIve been examined.Ten blood bags were taken from healthy volunteers andtudied serially for fibrinogen titre and thrombin clottingime. It has been found that •..- Fibrinogen titre does not change with storage of bloodover 7, 14 and 21 days.Significan t, gradual decrease in +h rornb Ln clotting timeoccured w~th storeee.In addition to dancers of platelet And leucocyte clump-19 by t r-an sf’uai on of stored blood, a progre su i ve al.o r t cn Lngf the thrombin clotting tDne of fibrinogen mey contribute orsu se hy pe r coagulDbi1:i.ty wi th increased risk to thrombosis.