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In vitro characterization of EHV-4 gG-deleted mutant
Faculty
Veterinary Medicine
Year:
2012
Type of Publication:
Article
Pages:
109-111
Authors:
Azab, Walid, El-Sheikh, Abuelyazeed, Abdel-Gawad, Azza
DOI:
10.1007/s11262-011-0677-6
Journal:
VIRUS GENES SPRINGER
Volume:
44
Research Area:
Genetics \& Heredity; Virology
ISSN
ISI:000299510900016
Keywords :
EHV-4, BAC, gG
Abstract:
Equine herpesvirus 4 (EHV-4) is an important pathogen that causes respiratory tract disease in horse populations worldwide. Glycoprotein G (gG) homologs have been identified in several alphaherpesviruses as minor non-essential membrane-anchored glycoproteins. In this study, EHV-4 gG deletion mutant has been generated by using bacterial artificial chromosome technology to investigate the role of gG in viral pathogenesis. Our findings reported here revealed no significant difference between parental EHV-4 and gG-negative strain in their replication cycle in cell culture. Furthermore, virus titers and plaque formation were comparable in both viruses. It is noteworthy that these findings disagree with the previously published study describing gG deletion in another EHV-4 strain.
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