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Preliminary assessment of potential toxicity of methylated soybean protein and methylated beta-lactoglobulin in male Wistar rats
Faculty
Agriculture
Year:
2013
Type of Publication:
Article
Pages:
618-625
Authors:
Sitohy, Mahmoud, Osman, Ali, Gharib, Ahmed, Chobert, Jean-Marc, Haertle, Thomas
DOI:
10.1016/j.fct.2013.06.026
Journal:
FOOD AND CHEMICAL TOXICOLOGY PERGAMON-ELSEVIER SCIENCE LTD
Volume:
59
Research Area:
Food Science \& Technology; Toxicology
ISSN
ISI:000324280000077
Keywords :
Toxicity, Renal function, Hepatic function, Histopathology, Methylated proteins, Serum proteins
Abstract:
Methylated soybean protein (MSP) and methylated beta-lactoglobulin (MLG), previously confirmed for their antibacterial and antiviral activities, were tested for their potential toxicity in Wistar male Albino rats as one single dose (2500, 5000 and 10,000 mg/kg body wt) or as repeated daily dose (500 and 2500 mg/kg body wt/day) over 28 days to assess potential toxicity. Single acute administration of very high doses (2500, 5000 and 10,000 mg/kg body wt) of MSP and MLG did not produce any mortality. Changes in body weight, organ weight, hematological parameters, histo-pathological images of selected organs, serum albumin, globulin and albumin/globulin ratio, cholesterol, triglycerides and electrolytes were all within normal amounts in the rats fed with these two methylated proteins and not significantly different from controls. The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine and urea were slightly reduced by the administration of these two modified proteins indicating the absence of any adverse effect on hepatic or renal functions. (c) 2013 Elsevier Ltd. All rights reserved.
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